nmt历*的今天
2017年11月07日,首都师范大学印莉萍、谭松利用nmt在traffic上发表了标题为tmd1 domain and crac motif determine the association and disassociation of mxirt1 with detergent‐resistant membranes
的研究成果。
期刊:traffic
主题:tmd1域和crac基序决定mxirt1与耐去污剂膜的缔合和解离
标题:tmd1 domain and crac motif determine the association and disassociation of mxirt1 with detergent‐resistant membranes
影响因子:4.133
检测指标:cd2+流速
作者:首都师范大学印莉萍、谭松
英文摘要
iron is essential for most living organisms. the iron‐regulated transporter1 (irt1) plays a major role in iron uptake in roots, and its trafficking from endoplasmic reticulum (er) to plasma membrane (pm) is tightly coordinated with changes in iron environment.
however, studies on the irt1 response are limited. here, we report that malus xiaojinesis irt1 (mxirt1) associates with detergent‐resistant membranes (drms, a biochemical counterpart of pm microdomains), whereas the pm microdomains are known platforms for signal transduction in the pm. depending on the shift of mxirt1 from microdomains to homogeneous regions in pm, mxirt1‐mediated iron absorption is activated by the cholesterol recognition/interaction amino acid consensus (crac) motif of mxirt1.
mxirt1 initially associates with drms in er via its transmembrane domain 1 (tmd1), and thus begins drms‐dependent intracellular trafficking. subsequently, mxirt1 is sequestered in copii vesicles via the er export signal sequence in mxirt1.
these studies suggest that iron homeostasis is influenced by the crac motif and tmd1 domain due to their determination of mxirt1‐drms association.
中文摘要(谷歌机翻)
铁对大多数生物都是*的。铁调节转运蛋白1(irt1)在根部吸收铁中起主要作用,其从内质网(er)到质膜(pm)的运输与铁环境的变化紧密相关。
但是,有关irt1反应的研究有限。在这里,我们报告说,小金海棠irt1(mxirt1)与耐去污剂的膜(drm,pm微域的生化对应物)相关,而pm微域是pm中信号转导的已知平台。取决于mxirt1从pm的微区到均质区的转移,mxirt1介导的铁吸收被mxirt1的*识别/相互作用氨基酸共有(crac)基序激活。
mxirt1初通过其跨膜结构域1(tmd1)与er中的drm结合,从而开始依赖drm的细胞内运输。随后,通过mxirt1中的er出口信号序列将mxirt1隔离在copii囊泡中。
这些研究表明,由于铁的动态平衡决定了mxirt1-drm的相关性,因此受crac基序和tmd1域的影响。
g) average cd2+flux in the different transgenic arabidopsis root hairs in 7-minute incubation with 0.05 mm cdcl2 measured by non-invasion micro-test technology. the bars represent the means standard errors of 3 independent analyses (n = 3). significant differences were determined by
student’s t test. *p < 0.05, **p < 0.01
精密机械加工中的小窍门,建议收藏!
不锈钢法兰球阀Q41F不锈钢球阀手动不锈钢304球阀的特点
压铸模具维护技术
热水高压清洗机正确的操作清洁流程是什么?
叶绿素荧光成像实例——水稻盐胁迫早期检测鉴定
NMT历*的今天丨Traffic 植物营养 文章发表
橡塑板生产厂家_地址
优冈股份 VMC-2150 VMC-2600 VMC-3200 立式加工中心机
邵氏硬度计有什么作用【全新上市】邵氏硬度计
试验机夹具的选择与使用
机床企业:用工匠精神去做生产
实验室器具清洗方法
发那科电源模块进水维修尽在同捷维修中心
单双层振筛机筛选方法
氧化物线状铜丝的用途能用在哪儿呢
药品Gmp车间认证需准备哪些材料
织物起毛起球性能测试方法解析
数控车床对刀具材料的要求
平面磨床的砂轮是什么?
空气滤清器的使用与维护