90plus 纳米粒度仪应用案例-26
文献名：zincoxideparticlesinduceinflammatoryresponsesinvascularendothelialcellsvianf-κbsignaling
作者：tsui-chuntsoua,szu-chingyeha,feng-yuantsaia,ho-janelina,tsun-jenchengb,how-ranchaoc,lin-aitaid
adivisionofenvironmentalhealthandoccupationalmedicine,nationalhealthresearchinstitutes,zhunan,miaolicounty,taiwan
binstituteofoccupationalmedicineandindustrialhygiene,nationaltaiwanuniversity,taipei,taiwan
cdepartmentofenvironmentalscienceandengineering,nationalpingtunguniversityofscienceandtechnology,neipu,pingtung,taiwan
dcenterfornanomedicineresearch,nationalhealthresearchinstitutes,zhunan,miaolicounty,taiwan
摘要：thisstudyinvestigatedinflammatoryeffectsofzincoxide(zno)particlesonvascularendothelialcells.theeffectsof50and100-nmznoparticlesonhumanumbilicalveinendothelialcells(huvecs)werecharacterizedbyassayingcytotoxicity,cellproliferation,andglutathionelevels.amarkeddropinsurvivalratewasobservedwhenznoconcentrationwasincreasedto45μg/ml.znoconcentrationsof≤3μg/mlresultedinincreasedcellproliferation,whilethoseof≤45μg/mlcauseddose-dependentincreasesinoxidizedglutathionelevels.treatmentswithznoconcentrations≤45μg/mlwereperformedtodeterminetheexpressionofintercellularadhesionmolecule-1(icam-1)protein,anindicatorofvascularendotheliuminflammation,revealingthatznoparticlesinducedadose-dependentincreaseinicam-1expressionandmarkedincreasesinnf-κbreporteractivity.overexpressionofiκbαcompleyinhibitedzno-inducedicam-1expression,suggestingnf-κbplaysapivotalroleinregulationofzno-inducedinflammationinhuvecs.additionally,tnf-α,atypicalinflammatorycytokine,inducedicam-1expressioninannf-κb-dependentmanner,andznosynergisticallyenhancedtnf-α-inducedicam-1expression.both50and100-nmznoparticlesagglomeratedtosimilarsizedistributions.thisstudyrevealsanimportantroleforznoinmodulatinginflammatoryresponsesofvascularendothelialcellsvianf-κbsignaling,whichcouldhaveimportantimplicationsfortreatmentsofvasculardisease.
关键词：zincoxide;endothelium;inflammation;nf-κb;adhesionmolecules;cytokines
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作者：tsui-chuntsoua,szu-chingyeha,feng-yuantsaia,ho-janelina,tsun-jenchengb,how-ranchaoc,lin-aitaid
adivisionofenvironmentalhealthandoccupationalmedicine,nationalhealthresearchinstitutes,zhunan,miaolicounty,taiwan
binstituteofoccupationalmedicineandindustrialhygiene,nationaltaiwanuniversity,taipei,taiwan
cdepartmentofenvironmentalscienceandengineering,nationalpingtunguniversityofscienceandtechnology,neipu,pingtung,taiwan
dcenterfornanomedicineresearch,nationalhealthresearchinstitutes,zhunan,miaolicounty,taiwan
摘要：thisstudyinvestigatedinflammatoryeffectsofzincoxide(zno)particlesonvascularendothelialcells.theeffectsof50and100-nmznoparticlesonhumanumbilicalveinendothelialcells(huvecs)werecharacterizedbyassayingcytotoxicity,cellproliferation,andglutathionelevels.amarkeddropinsurvivalratewasobservedwhenznoconcentrationwasincreasedto45μg/ml.znoconcentrationsof≤3μg/mlresultedinincreasedcellproliferation,whilethoseof≤45μg/mlcauseddose-dependentincreasesinoxidizedglutathionelevels.treatmentswithznoconcentrations≤45μg/mlwereperformedtodeterminetheexpressionofintercellularadhesionmolecule-1(icam-1)protein,anindicatorofvascularendotheliuminflammation,revealingthatznoparticlesinducedadose-dependentincreaseinicam-1expressionandmarkedincreasesinnf-κbreporteractivity.overexpressionofiκbαcompleyinhibitedzno-inducedicam-1expression,suggestingnf-κbplaysapivotalroleinregulationofzno-inducedinflammationinhuvecs.additionally,tnf-α,atypicalinflammatorycytokine,inducedicam-1expressioninannf-κb-dependentmanner,andznosynergisticallyenhancedtnf-α-inducedicam-1expression.both50and100-nmznoparticlesagglomeratedtosimilarsizedistributions.thisstudyrevealsanimportantroleforznoinmodulatinginflammatoryresponsesofvascularendothelialcellsvianf-κbsignaling,whichcouldhaveimportantimplicationsfortreatmentsofvasculardisease.
关键词：zincoxide;endothelium;inflammation;nf-κb;adhesionmolecules;cytokines
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气相色谱仪的主要部件及功能
六级筛孔撞击式空气微生物采样器有什么用
一体化预制泵站是什么东西？
解决药品生产安全问题，制药装备企业有待向“新高度”进军
离子色谱法测定电镀液中F-和CI-
每时1吨地埋式污水处理设备质量
使用吸污净化车时，应注意以下事项
Leybold德国莱宝真空泵选择以及安装方法
电解法次氯酸钠发生器采用的是可再生能源电力
智能实验室系统的结构系统组成和控制模式
红条纹橡胶板产品工艺
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